Serveur d'exploration sur les relations entre la France et l'Australie

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010

Identifieur interne : 004083 ( Main/Exploration ); précédent : 004082; suivant : 004084

Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010

Auteurs : A. N. Balamurugan [États-Unis] ; B. Naziruddin [États-Unis] ; A. Lockridge [États-Unis] ; M. Tiwari [États-Unis] ; G. Loganathan [États-Unis] ; M. Takita [États-Unis] ; S. Matsumoto [Japon] ; K. Papas [États-Unis] ; M. Trieger [États-Unis] ; H. Rainis [États-Unis] ; T. Kin [États-Unis] ; T. W. Kay [Australie] ; S. Wease [États-Unis] ; S. Messinger [États-Unis] ; C. Ricordi [États-Unis] ; R. Alejandro [États-Unis] ; J. Markmann [États-Unis] ; J. Kerr-Conti [France] ; M. R. Rickels [États-Unis] ; C. Liu [États-Unis] ; X. Zhang [États-Unis] ; P. Witkowski [États-Unis] ; A. Posselt [États-Unis] ; P. Maffi [Italie] ; A. Secchi [Italie] ; T. Berney [Suisse] ; P. J. O'Connell [Australie] ; B. J. Hering [États-Unis] ; F. B. Barton [États-Unis]

Source :

RBID : Pascal:15-0002622

Descripteurs français

English descriptors

Abstract

The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 × 103 IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999-2010, and these parallel improvements in clinical outcomes over the same period.

Url:


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en" level="a">Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010</title>
<author>
<name sortKey="Balamurugan, A N" sort="Balamurugan, A N" uniqKey="Balamurugan A" first="A. N." last="Balamurugan">A. N. Balamurugan</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Naziruddin, B" sort="Naziruddin, B" uniqKey="Naziruddin B" first="B." last="Naziruddin">B. Naziruddin</name>
<affiliation wicri:level="1">
<inist:fA14 i1="02">
<s1>Baylor Annette C. and Harold C. Simmons Transplant Institute</s1>
<s2>Dallas, TX</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Baylor Annette C. and Harold C. Simmons Transplant Institute</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lockridge, A" sort="Lockridge, A" uniqKey="Lockridge A" first="A." last="Lockridge">A. Lockridge</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Tiwari, M" sort="Tiwari, M" uniqKey="Tiwari M" first="M." last="Tiwari">M. Tiwari</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Loganathan, G" sort="Loganathan, G" uniqKey="Loganathan G" first="G." last="Loganathan">G. Loganathan</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Takita, M" sort="Takita, M" uniqKey="Takita M" first="M." last="Takita">M. Takita</name>
<affiliation wicri:level="1">
<inist:fA14 i1="02">
<s1>Baylor Annette C. and Harold C. Simmons Transplant Institute</s1>
<s2>Dallas, TX</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Baylor Annette C. and Harold C. Simmons Transplant Institute</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Matsumoto, S" sort="Matsumoto, S" uniqKey="Matsumoto S" first="S." last="Matsumoto">S. Matsumoto</name>
<affiliation wicri:level="1">
<inist:fA14 i1="03">
<s1>Research and Development Center, Otsuka Pharmaceutical Factory, Inc.</s1>
<s2>Tokushima</s2>
<s3>JPN</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Tokushima</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Papas, K" sort="Papas, K" uniqKey="Papas K" first="K." last="Papas">K. Papas</name>
<affiliation wicri:level="1">
<inist:fA14 i1="04">
<s1>Institute for Cellular Transplantation, University of Arizona</s1>
<s2>Tucson, AZ</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Tucson, AZ</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Trieger, M" sort="Trieger, M" uniqKey="Trieger M" first="M." last="Trieger">M. Trieger</name>
<affiliation wicri:level="1">
<inist:fA14 i1="05">
<s1>The EMMES Corporation</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The EMMES Corporation</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rainis, H" sort="Rainis, H" uniqKey="Rainis H" first="H." last="Rainis">H. Rainis</name>
<affiliation wicri:level="1">
<inist:fA14 i1="05">
<s1>The EMMES Corporation</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The EMMES Corporation</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kin, T" sort="Kin, T" uniqKey="Kin T" first="T." last="Kin">T. Kin</name>
<affiliation wicri:level="1">
<inist:fA14 i1="06">
<s1>Clinical Islet Laboratory, University of Alberta</s1>
<s2>Edmonton, AB</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Edmonton, AB</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kay, T W" sort="Kay, T W" uniqKey="Kay T" first="T. W." last="Kay">T. W. Kay</name>
<affiliation wicri:level="3">
<inist:fA14 i1="07">
<s1>St. Vincent's Hospital</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wease, S" sort="Wease, S" uniqKey="Wease S" first="S." last="Wease">S. Wease</name>
<affiliation wicri:level="1">
<inist:fA14 i1="05">
<s1>The EMMES Corporation</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The EMMES Corporation</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Messinger, S" sort="Messinger, S" uniqKey="Messinger S" first="S." last="Messinger">S. Messinger</name>
<affiliation wicri:level="1">
<inist:fA14 i1="08">
<s1>Department of Public Health Services, University of Miami</s1>
<s2>Miami, FL</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Miami, FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ricordi, C" sort="Ricordi, C" uniqKey="Ricordi C" first="C." last="Ricordi">C. Ricordi</name>
<affiliation wicri:level="1">
<inist:fA14 i1="09">
<s1>Diabetes Research Institute, University of Miami</s1>
<s2>Miami, FL</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Miami, FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Alejandro, R" sort="Alejandro, R" uniqKey="Alejandro R" first="R." last="Alejandro">R. Alejandro</name>
<affiliation wicri:level="1">
<inist:fA14 i1="09">
<s1>Diabetes Research Institute, University of Miami</s1>
<s2>Miami, FL</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Miami, FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Markmann, J" sort="Markmann, J" uniqKey="Markmann J" first="J." last="Markmann">J. Markmann</name>
<affiliation wicri:level="1">
<inist:fA14 i1="10">
<s1>Department of Surgery, Massachusetts General Hospital</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kerr Conti, J" sort="Kerr Conti, J" uniqKey="Kerr Conti J" first="J." last="Kerr-Conti">J. Kerr-Conti</name>
<affiliation wicri:level="3">
<inist:fA14 i1="11">
<s1>Lille University Hospital</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rickels, M R" sort="Rickels, M R" uniqKey="Rickels M" first="M. R." last="Rickels">M. R. Rickels</name>
<affiliation wicri:level="1">
<inist:fA14 i1="12">
<s1>Department of Medicine, University of Pennsylvania</s1>
<s2>Philadelphia, PA</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Philadelphia, PA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Liu, C" sort="Liu, C" uniqKey="Liu C" first="C." last="Liu">C. Liu</name>
<affiliation wicri:level="1">
<inist:fA14 i1="13">
<s1>Department of Surgery, University of Pennsylvania</s1>
<s2>Philadelphia, PA</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Philadelphia, PA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Zhang, X" sort="Zhang, X" uniqKey="Zhang X" first="X." last="Zhang">X. Zhang</name>
<affiliation wicri:level="1">
<inist:fA14 i1="14">
<s1>Feinberg School of Medicine, Northwestern University</s1>
<s2>Chicago, IL</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Chicago, IL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Witkowski, P" sort="Witkowski, P" uniqKey="Witkowski P" first="P." last="Witkowski">P. Witkowski</name>
<affiliation wicri:level="1">
<inist:fA14 i1="15">
<s1>Department of Surgery, University of Chicago</s1>
<s2>Chicago, IL</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Chicago, IL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Posselt, A" sort="Posselt, A" uniqKey="Posselt A" first="A." last="Posselt">A. Posselt</name>
<affiliation wicri:level="3">
<inist:fA14 i1="16">
<s1>Department of Surgery, University of California, San Francisco</s1>
<s2>San Francisco, CA</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName>
<settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Maffi, P" sort="Maffi, P" uniqKey="Maffi P" first="P." last="Maffi">P. Maffi</name>
<affiliation wicri:level="3">
<inist:fA14 i1="17">
<s1>Vita-Salute, San Raffaele University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Secchi, A" sort="Secchi, A" uniqKey="Secchi A" first="A." last="Secchi">A. Secchi</name>
<affiliation wicri:level="3">
<inist:fA14 i1="17">
<s1>Vita-Salute, San Raffaele University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Berney, T" sort="Berney, T" uniqKey="Berney T" first="T." last="Berney">T. Berney</name>
<affiliation wicri:level="1">
<inist:fA14 i1="18">
<s1>Department of Surgery, Geneva University Hospital</s1>
<s2>Geneva</s2>
<s3>CHE</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="O Connell, P J" sort="O Connell, P J" uniqKey="O Connell P" first="P. J." last="O'Connell">P. J. O'Connell</name>
<affiliation wicri:level="3">
<inist:fA14 i1="19">
<s1>National Pancreas Transplant Unit, University of Sydney at Westmead Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hering, B J" sort="Hering, B J" uniqKey="Hering B" first="B. J." last="Hering">B. J. Hering</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Barton, F B" sort="Barton, F B" uniqKey="Barton F" first="F. B." last="Barton">F. B. Barton</name>
<affiliation wicri:level="1">
<inist:fA14 i1="05">
<s1>The EMMES Corporation</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The EMMES Corporation</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">INIST</idno>
<idno type="inist">15-0002622</idno>
<date when="2014">2014</date>
<idno type="stanalyst">PASCAL 15-0002622 INIST</idno>
<idno type="RBID">Pascal:15-0002622</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000155</idno>
<idno type="wicri:Area/PascalFrancis/Curation">005C98</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000221</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000221</idno>
<idno type="wicri:doubleKey">1600-6135:2014:Balamurugan A:islet:product:characteristics</idno>
<idno type="wicri:Area/Main/Merge">004145</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282081</idno>
<idno type="RBID">PMC:4282081</idno>
<idno type="wicri:Area/Pmc/Corpus">002234</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002234</idno>
<idno type="wicri:Area/Pmc/Curation">002084</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002084</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001498</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001498</idno>
<idno type="wicri:Area/Ncbi/Merge">001E67</idno>
<idno type="wicri:Area/Ncbi/Curation">001E67</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001E67</idno>
<idno type="wicri:doubleKey">1600-6135:2014:Balamurugan A:islet:product:characteristics</idno>
<idno type="wicri:Area/Main/Merge">003798</idno>
<idno type="wicri:Area/Main/Curation">004083</idno>
<idno type="wicri:Area/Main/Exploration">004083</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a">Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010</title>
<author>
<name sortKey="Balamurugan, A N" sort="Balamurugan, A N" uniqKey="Balamurugan A" first="A. N." last="Balamurugan">A. N. Balamurugan</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Naziruddin, B" sort="Naziruddin, B" uniqKey="Naziruddin B" first="B." last="Naziruddin">B. Naziruddin</name>
<affiliation wicri:level="1">
<inist:fA14 i1="02">
<s1>Baylor Annette C. and Harold C. Simmons Transplant Institute</s1>
<s2>Dallas, TX</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Baylor Annette C. and Harold C. Simmons Transplant Institute</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lockridge, A" sort="Lockridge, A" uniqKey="Lockridge A" first="A." last="Lockridge">A. Lockridge</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Tiwari, M" sort="Tiwari, M" uniqKey="Tiwari M" first="M." last="Tiwari">M. Tiwari</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Loganathan, G" sort="Loganathan, G" uniqKey="Loganathan G" first="G." last="Loganathan">G. Loganathan</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Takita, M" sort="Takita, M" uniqKey="Takita M" first="M." last="Takita">M. Takita</name>
<affiliation wicri:level="1">
<inist:fA14 i1="02">
<s1>Baylor Annette C. and Harold C. Simmons Transplant Institute</s1>
<s2>Dallas, TX</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Baylor Annette C. and Harold C. Simmons Transplant Institute</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Matsumoto, S" sort="Matsumoto, S" uniqKey="Matsumoto S" first="S." last="Matsumoto">S. Matsumoto</name>
<affiliation wicri:level="1">
<inist:fA14 i1="03">
<s1>Research and Development Center, Otsuka Pharmaceutical Factory, Inc.</s1>
<s2>Tokushima</s2>
<s3>JPN</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Tokushima</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Papas, K" sort="Papas, K" uniqKey="Papas K" first="K." last="Papas">K. Papas</name>
<affiliation wicri:level="1">
<inist:fA14 i1="04">
<s1>Institute for Cellular Transplantation, University of Arizona</s1>
<s2>Tucson, AZ</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Tucson, AZ</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Trieger, M" sort="Trieger, M" uniqKey="Trieger M" first="M." last="Trieger">M. Trieger</name>
<affiliation wicri:level="1">
<inist:fA14 i1="05">
<s1>The EMMES Corporation</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The EMMES Corporation</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rainis, H" sort="Rainis, H" uniqKey="Rainis H" first="H." last="Rainis">H. Rainis</name>
<affiliation wicri:level="1">
<inist:fA14 i1="05">
<s1>The EMMES Corporation</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The EMMES Corporation</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kin, T" sort="Kin, T" uniqKey="Kin T" first="T." last="Kin">T. Kin</name>
<affiliation wicri:level="1">
<inist:fA14 i1="06">
<s1>Clinical Islet Laboratory, University of Alberta</s1>
<s2>Edmonton, AB</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Edmonton, AB</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kay, T W" sort="Kay, T W" uniqKey="Kay T" first="T. W." last="Kay">T. W. Kay</name>
<affiliation wicri:level="3">
<inist:fA14 i1="07">
<s1>St. Vincent's Hospital</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wease, S" sort="Wease, S" uniqKey="Wease S" first="S." last="Wease">S. Wease</name>
<affiliation wicri:level="1">
<inist:fA14 i1="05">
<s1>The EMMES Corporation</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The EMMES Corporation</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Messinger, S" sort="Messinger, S" uniqKey="Messinger S" first="S." last="Messinger">S. Messinger</name>
<affiliation wicri:level="1">
<inist:fA14 i1="08">
<s1>Department of Public Health Services, University of Miami</s1>
<s2>Miami, FL</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Miami, FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ricordi, C" sort="Ricordi, C" uniqKey="Ricordi C" first="C." last="Ricordi">C. Ricordi</name>
<affiliation wicri:level="1">
<inist:fA14 i1="09">
<s1>Diabetes Research Institute, University of Miami</s1>
<s2>Miami, FL</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Miami, FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Alejandro, R" sort="Alejandro, R" uniqKey="Alejandro R" first="R." last="Alejandro">R. Alejandro</name>
<affiliation wicri:level="1">
<inist:fA14 i1="09">
<s1>Diabetes Research Institute, University of Miami</s1>
<s2>Miami, FL</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Miami, FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Markmann, J" sort="Markmann, J" uniqKey="Markmann J" first="J." last="Markmann">J. Markmann</name>
<affiliation wicri:level="1">
<inist:fA14 i1="10">
<s1>Department of Surgery, Massachusetts General Hospital</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kerr Conti, J" sort="Kerr Conti, J" uniqKey="Kerr Conti J" first="J." last="Kerr-Conti">J. Kerr-Conti</name>
<affiliation wicri:level="3">
<inist:fA14 i1="11">
<s1>Lille University Hospital</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rickels, M R" sort="Rickels, M R" uniqKey="Rickels M" first="M. R." last="Rickels">M. R. Rickels</name>
<affiliation wicri:level="1">
<inist:fA14 i1="12">
<s1>Department of Medicine, University of Pennsylvania</s1>
<s2>Philadelphia, PA</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Philadelphia, PA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Liu, C" sort="Liu, C" uniqKey="Liu C" first="C." last="Liu">C. Liu</name>
<affiliation wicri:level="1">
<inist:fA14 i1="13">
<s1>Department of Surgery, University of Pennsylvania</s1>
<s2>Philadelphia, PA</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Philadelphia, PA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Zhang, X" sort="Zhang, X" uniqKey="Zhang X" first="X." last="Zhang">X. Zhang</name>
<affiliation wicri:level="1">
<inist:fA14 i1="14">
<s1>Feinberg School of Medicine, Northwestern University</s1>
<s2>Chicago, IL</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Chicago, IL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Witkowski, P" sort="Witkowski, P" uniqKey="Witkowski P" first="P." last="Witkowski">P. Witkowski</name>
<affiliation wicri:level="1">
<inist:fA14 i1="15">
<s1>Department of Surgery, University of Chicago</s1>
<s2>Chicago, IL</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Chicago, IL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Posselt, A" sort="Posselt, A" uniqKey="Posselt A" first="A." last="Posselt">A. Posselt</name>
<affiliation wicri:level="3">
<inist:fA14 i1="16">
<s1>Department of Surgery, University of California, San Francisco</s1>
<s2>San Francisco, CA</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName>
<settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Maffi, P" sort="Maffi, P" uniqKey="Maffi P" first="P." last="Maffi">P. Maffi</name>
<affiliation wicri:level="3">
<inist:fA14 i1="17">
<s1>Vita-Salute, San Raffaele University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Secchi, A" sort="Secchi, A" uniqKey="Secchi A" first="A." last="Secchi">A. Secchi</name>
<affiliation wicri:level="3">
<inist:fA14 i1="17">
<s1>Vita-Salute, San Raffaele University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Berney, T" sort="Berney, T" uniqKey="Berney T" first="T." last="Berney">T. Berney</name>
<affiliation wicri:level="1">
<inist:fA14 i1="18">
<s1>Department of Surgery, Geneva University Hospital</s1>
<s2>Geneva</s2>
<s3>CHE</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="O Connell, P J" sort="O Connell, P J" uniqKey="O Connell P" first="P. J." last="O'Connell">P. J. O'Connell</name>
<affiliation wicri:level="3">
<inist:fA14 i1="19">
<s1>National Pancreas Transplant Unit, University of Sydney at Westmead Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hering, B J" sort="Hering, B J" uniqKey="Hering B" first="B. J." last="Hering">B. J. Hering</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Barton, F B" sort="Barton, F B" uniqKey="Barton F" first="F. B." last="Barton">F. B. Barton</name>
<affiliation wicri:level="1">
<inist:fA14 i1="05">
<s1>The EMMES Corporation</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The EMMES Corporation</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j" type="main">American journal of transplantation : (Print)</title>
<title level="j" type="abbreviated">Am. j. transplant. : (Print)</title>
<idno type="ISSN">1600-6135</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<title level="j" type="main">American journal of transplantation : (Print)</title>
<title level="j" type="abbreviated">Am. j. transplant. : (Print)</title>
<idno type="ISSN">1600-6135</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>1999</term>
<term>Characteristics</term>
<term>Diabetes mellitus</term>
<term>Graft</term>
<term>Homograft</term>
<term>Human</term>
<term>Langerhans islet</term>
<term>Public health</term>
<term>Register</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Greffe</term>
<term>Ilot Langerhans</term>
<term>Caractéristiques</term>
<term>Homogreffe</term>
<term>Homme</term>
<term>Registre</term>
<term>Diabète</term>
<term>1999</term>
<term>Santé publique</term>
<term>2010</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Homme</term>
<term>Diabète</term>
<term>Santé publique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 × 10
<sup>3 </sup>
IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999-2010, and these parallel improvements in clinical outcomes over the same period.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Australie</li>
<li>France</li>
<li>Italie</li>
<li>Japon</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region>
<li>Californie</li>
<li>Hauts-de-France</li>
<li>Lombardie</li>
<li>Nord-Pas-de-Calais</li>
<li>Nouvelle-Galles du Sud</li>
<li>Victoria (État)</li>
</region>
<settlement>
<li>Lille</li>
<li>Melbourne</li>
<li>Milan</li>
<li>San Francisco</li>
<li>Sydney</li>
</settlement>
</list>
<tree>
<country name="États-Unis">
<noRegion>
<name sortKey="Balamurugan, A N" sort="Balamurugan, A N" uniqKey="Balamurugan A" first="A. N." last="Balamurugan">A. N. Balamurugan</name>
</noRegion>
<name sortKey="Alejandro, R" sort="Alejandro, R" uniqKey="Alejandro R" first="R." last="Alejandro">R. Alejandro</name>
<name sortKey="Barton, F B" sort="Barton, F B" uniqKey="Barton F" first="F. B." last="Barton">F. B. Barton</name>
<name sortKey="Hering, B J" sort="Hering, B J" uniqKey="Hering B" first="B. J." last="Hering">B. J. Hering</name>
<name sortKey="Kin, T" sort="Kin, T" uniqKey="Kin T" first="T." last="Kin">T. Kin</name>
<name sortKey="Liu, C" sort="Liu, C" uniqKey="Liu C" first="C." last="Liu">C. Liu</name>
<name sortKey="Lockridge, A" sort="Lockridge, A" uniqKey="Lockridge A" first="A." last="Lockridge">A. Lockridge</name>
<name sortKey="Loganathan, G" sort="Loganathan, G" uniqKey="Loganathan G" first="G." last="Loganathan">G. Loganathan</name>
<name sortKey="Markmann, J" sort="Markmann, J" uniqKey="Markmann J" first="J." last="Markmann">J. Markmann</name>
<name sortKey="Messinger, S" sort="Messinger, S" uniqKey="Messinger S" first="S." last="Messinger">S. Messinger</name>
<name sortKey="Naziruddin, B" sort="Naziruddin, B" uniqKey="Naziruddin B" first="B." last="Naziruddin">B. Naziruddin</name>
<name sortKey="Papas, K" sort="Papas, K" uniqKey="Papas K" first="K." last="Papas">K. Papas</name>
<name sortKey="Posselt, A" sort="Posselt, A" uniqKey="Posselt A" first="A." last="Posselt">A. Posselt</name>
<name sortKey="Rainis, H" sort="Rainis, H" uniqKey="Rainis H" first="H." last="Rainis">H. Rainis</name>
<name sortKey="Rickels, M R" sort="Rickels, M R" uniqKey="Rickels M" first="M. R." last="Rickels">M. R. Rickels</name>
<name sortKey="Ricordi, C" sort="Ricordi, C" uniqKey="Ricordi C" first="C." last="Ricordi">C. Ricordi</name>
<name sortKey="Takita, M" sort="Takita, M" uniqKey="Takita M" first="M." last="Takita">M. Takita</name>
<name sortKey="Tiwari, M" sort="Tiwari, M" uniqKey="Tiwari M" first="M." last="Tiwari">M. Tiwari</name>
<name sortKey="Trieger, M" sort="Trieger, M" uniqKey="Trieger M" first="M." last="Trieger">M. Trieger</name>
<name sortKey="Wease, S" sort="Wease, S" uniqKey="Wease S" first="S." last="Wease">S. Wease</name>
<name sortKey="Witkowski, P" sort="Witkowski, P" uniqKey="Witkowski P" first="P." last="Witkowski">P. Witkowski</name>
<name sortKey="Zhang, X" sort="Zhang, X" uniqKey="Zhang X" first="X." last="Zhang">X. Zhang</name>
</country>
<country name="Japon">
<noRegion>
<name sortKey="Matsumoto, S" sort="Matsumoto, S" uniqKey="Matsumoto S" first="S." last="Matsumoto">S. Matsumoto</name>
</noRegion>
</country>
<country name="Australie">
<region name="Victoria (État)">
<name sortKey="Kay, T W" sort="Kay, T W" uniqKey="Kay T" first="T. W." last="Kay">T. W. Kay</name>
</region>
<name sortKey="O Connell, P J" sort="O Connell, P J" uniqKey="O Connell P" first="P. J." last="O'Connell">P. J. O'Connell</name>
</country>
<country name="France">
<region name="Hauts-de-France">
<name sortKey="Kerr Conti, J" sort="Kerr Conti, J" uniqKey="Kerr Conti J" first="J." last="Kerr-Conti">J. Kerr-Conti</name>
</region>
</country>
<country name="Italie">
<region name="Lombardie">
<name sortKey="Maffi, P" sort="Maffi, P" uniqKey="Maffi P" first="P." last="Maffi">P. Maffi</name>
</region>
<name sortKey="Secchi, A" sort="Secchi, A" uniqKey="Secchi A" first="A." last="Secchi">A. Secchi</name>
</country>
<country name="Suisse">
<noRegion>
<name sortKey="Berney, T" sort="Berney, T" uniqKey="Berney T" first="T." last="Berney">T. Berney</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004083 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004083 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:15-0002622
   |texte=   Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010
}}

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024